Multiscale Cancer Modelling and in Silico Medicine (MSCM & ISM)


Code 705
Semester Fall
Class Hours - Lab Hours 3 - 0
Lecturers Georgios Stamatakos (I.C.C.S. Researcher), Γεώργιος Σταματάκος

Description

The course provides an introduction to the emergent scientific, technological and clinical domain of in silico medicine (https://en.wikipedia.org/wiki/In_silico_medicine ) along with concrete and in depth modelling, simulation and clinical validation examples from various areas of the domain.Multiscale cancer modelling serves as the example par excellence of the means for founding and shaping the new discipline. Examples from several other areas including inter alia cardiology, neurology and clinical pharmacology are also included.

The coursefocuses on the following topics:

  1. Introduction to Multiscale Disease Modelling (MSDM) and In Silico Medicine (ISM) .The paradigm of Multi-scale Cancer Modelling (MSCM) and In Silico Oncology (ISO)
  2. In Silico Medicine / In Silico Oncology (ISM/ISO): Fundamental science aspects. The Oncosimulator.
  3. ISM/ISO: Technological aspects
  4. ISI/ISO: Clinical requirements and clinical application aspects
  5. Mathematical model formulation of clinical tumour invasion using the partial differential equation of diffusion-reaction with pertinent boundary conditions. Analogies with, extensions to and examples of other diseases and treatments in the generic ISM context.
  6. Numerical methods for the solution of the spatio-temporal problem of tumour invasion into normal tissues including an explicit consideration of the boundary conditions. Analogies with, extensions to and examples of other diseases and treatments in the generic ISM context.
  7. Modelling and simulation of angiogenesis during tumour growth. Analogies with, extensions to and examples of other diseases and treatments in the generic ISM context.
  8. Modelling and simulation of molecular interactions, molecular pathways, molecular signal transmission and the resulting behaviour of the cancer cell.Analogies with, extensions toand examples of other diseases and treatments in the generic ISM context.

The basictextbook used in the course is entitled "Multiscale Cancer Modeling", CRC Press, 2010/2011 and has beenedited by Tomas Deisboeck and Georgios S .Stamatakos
(http://www.crcnetbase.com/isbn/9781439814420). Its content is enhanced and extended to several other areas byadditional material including inter aliathe Proceedings of the Virtual Physiological Human Conference held in London in 2012: "VPH2012 – Integrative Approaches to Computational Biomedicine", several scientific papers, relevant simulation videos and three- dimensionalbiochemical and anatomical models.

The assessment score is based on the production of a critical literature review paper (LRP) - different for each student - and the common written exam (CWE). The LPR score contributes 60% and the CWE 40% to the final assessment score.Α news release of the Virtual Physiological Human Institute (VPHI) on the new postgraduate course on MSCM & ISM is available at http://www.vph-institute.org/news/new-postgraduate-subject-on-multiscale-cancer-modelling-and-in-silico-medicine-mscm-ism.html