PhD thesis defense to be held on July 29, 2025, at 14:00 (Via internet, MS Teams)
Thesis title: TECHNOLOGIES FOR THE DEVELOPMENT OF INTEGRATED ONCOSIMULATORS
Abstract: The purpose of this doctoral dissertation is to document the technologies for developing integrated Oncosimulators. The need for such a process arises from the fact that a simulation model basically remains a piece of software whose input and output, in their original forms, indeed provide the necessary clinical information for drawing conclusions, but in a format not immediately or easily readable and understandable by either the researcher or the clinician.
As a proposal for the solution of this significant issue, which ultimately aims at the clinical application of the concept of personalized medicine, a computational infrastructure is proposed. Its basic functionality focuses on storing the characteristics of a simulation model, including its relevant executable and accompanying files. Initially, an introduction is given to the basic principles of development and functionality of such an infrastructure, while proposed extensions for handling semantic data and clinical questions are presented. At the same time, through the results of successful European research programs, use cases of simulation models are presented to which the aforementioned infrastructure can contribute, in order to promote their transition to daily clinical practice, such as the use of Oncosimulators in a Clinical Decision Support System.
Subsequently, an original implementation of the aforementioned infrastructure is provided. It includes a description of the technologies and design techniques used, the individual parts into which it is divided, and its use cases. Then, the results of using the implemented application through these scenarios are presented. Finally, a brief summary is given, which also includes future extensions.
Supervisor: Professor Nikolaos Uzunoglu
PhD Student: Nikolaos Christodoulou